MTP - Dosage for 1st & 2nd Trimester

Dosages of Mifepristone and Misoprostol for First and Second Trimester Abortions

First Trimester (Up to 10 Weeks)

Mifepristone:

Dosage: 200 mg orally as a single dose on Day 1.

Misoprostol:

Dosage: 800 mcg (four 200 mcg tablets) taken buccally (between the cheek and gum) 24 to 48 hours after taking mifepristone.

Administration: The tablets are placed between the cheek and gum for 30 minutes, then swallowed with water.

Second Trimester (10-24 Weeks)

Mifepristone:

Dosage: 200 mg orally as a single dose, typically administered 24 hours before misoprostol.

Misoprostol:

Dosage: 400 mcg vaginally every 3 hours until the abortion is complete. The total dose can range from 800 mcg to 3,600 mcg depending on the specific regimen and patient response.

Administration: The misoprostol tablets are inserted vaginally at the appropriate dosage and time intervals.

Additional Information

First Trimester Regimen: This regimen is highly effective, with a success rate of approximately 95% when taken within the first 11 weeks of pregnancy.

Second Trimester Regimen: The success rate for second-trimester abortions using misoprostol alone is about 92.1%. The combination of mifepristone and misoprostol is often used to enhance effectiveness and reduce the time required for the abortion process.

Safety and Follow-Up

Safety: Both mifepristone and misoprostol are considered safe when used as directed. However, they can cause side effects such as nausea, vomiting, diarrhea, abdominal pain, and vaginal bleeding. Serious complications are rare but can include heavy bleeding and infection.

Follow-Up: A follow-up visit with a healthcare provider is recommended about 7 to 14 days after taking the medications to confirm the completion of the abortion and to check for any complications.